A nationwide manhunt for Hank Venture leads to untold dangers and unexpected revelations, while The Monarch is literally out for Dr Venture's blood. An imposing evil from the past reemerges to wreak havoc on the Ventures, The Guild, and even the Monarch marriage—it will take friends and foes alike to restore the Ventures' world to order… or end it once and for all.

Cast: James Urbaniak, Patrick Warburton, Michael Sinterniklaas, Doc Hammer, Christopher McCulloch, Nina Arianda